| C.J. Stroud | HOU | 5059 | Joe Burrow | CIN | 4212 | Lamar Jackson | BAL | 4128 | J.J. McCarthy | MIN | 4017 | Will Levis | TEN | 3988 |
| Travis Etienne Jr | JAX | 1285 | Imani Younger | LV | 1195 | Aaron Jones | DAL | 1190 | Jonathan Taylor | IND | 1138 | Trey Benson | ARI | 1094 |
| Stefon Diggs | HOU | 1994 | Rome Odunze | CHI | 1418 | Puka Nacua | LAR | 1270 | Justin Jefferson | MIN | 1206 | Tee Higgins | CIN | 1126 |
| Justin Garfield | CAR | 964 | Travis Kelce | KC | 960 | Kyle Pitts | ATL | 919 | David Njoku | CLE | 888 | Brock Bowers | LV | 866 |
Defensive Leaders
| Nick Bosa | SF | 14.0 | Maxx Crosby | LV | 13.5 | Trenton Simpson | BAL | 12.0 | Sam Williams | DAL | 11.5 | Myles Garrett | CLE | 11.5 |
| Ernest Jones | TEN | 80 | Jordyn Brooks | MIA | 76 | Edgerrin Cooper | GB | 76 | Blake Cashman | MIN | 70 | Cody Barton | DEN | 70 |
| Minkah Fitzpatrick | PIT | 9 | Jeremiah Owusu-Koramoah | CLE | 8 | L'Jarius Sneed | TEN | 7 | Trevon Diggs | DAL | 6 | Jessie Bates III | ATL | 6 |
| Patrick Queen | PIT | 3 | Stephon Gilmore | BUF | 3 | Joey Porter | PIT | 3 | Dillon Northcutt | CLE | 3 | Fred Warner | SF | 3 |
Special Teams Leaders
| Justin Tucker | BAL | 121 | Jake Bates | CAR | 112 | Chris Boswell | PIT | 112 | Brandon Aubrey | DAL | 111 | Evan McPherson | CIN | 111 |
| Blake Gillikin | ARI | 2851 | Mitch Wishnowsky | SF | 2824 | Ryan Stonehouse | DET | 2644 | Jake Camarda | TB | 2606 | Bryce Baringer | NE | 2585 |