| J.J. McCarthy | MIN | 2874 |
| Caleb Williams | CHI | 2857 |
| Joe Burrow | CIN | 2688 |
| Lamar Jackson | BAL | 2485 |
| Josh Allen | BUF | 2481 |
| Josh Jacobs | GB | 995 |
| Jaylen Warren | PIT | 811 |
| Travis Etienne Jr | JAX | 753 |
| Joe Mixon | NYG | 739 |
| Bijan Robinson | ATL | 696 |
| Rome Odunze | CHI | 1124 |
| Stefon Diggs | HOU | 897 |
| Puka Nacua | LAR | 886 |
| D.J. Moore | CHI | 780 |
| Zay Flowers | BAL | 751 |
| Brock Bowers | LV | 625 |
| Hunter Henry | NE | 609 |
| Luke Schoonmaker | DAL | 584 |
| Devin Payne | NYJ | 566 |
| Pat Freiermuth | PIT | 558 |
Defensive Leaders
| Derrick Brown | CAR | 7.5 |
| Braden Fiske | LAR | 7.5 |
| Alim McNeill | DET | 7.0 |
| Shaquille Johnson | TB | 7.0 |
| Jared Verse | LAR | 6.0 |
| Dillon Northcutt | CLE | 64 |
| Kyzir White | TB | 59 |
| Jamin Davis | WAS | 56 |
| Devin Bush | ATL | 54 |
| Micah McFadden | NYG | 52 |
| Kool-Aid McKinstry | NO | 6 |
| Martin Emerson Jr | LV | 5 |
| Taron Johnson | BUF | 4 |
| Jeremiah Owusu-Koramoah | CLE | 4 |
| Trevon Diggs | DAL | 4 |
| Patrick Queen | PIT | 3 |
| Beanie Bishop Jr | PIT | 3 |
| Micah Parsons | DAL | 2 |
| Renardo Green | SF | 2 |
| Trent Yates | CAR | 2 |
Special Teams Leaders
| Ka'imi Fairbairn | HOU | 76 |
| Daniel Carlson | LV | 73 |
| Riley Patterson | LAR | 70 |
| Justin Tucker | BAL | 69 |
| Jake Bates | CAR | 68 |
| Logan Cooke | WAS | 2187 |
| Mitch Wishnowsky | SF | 1912 |
| Chad Schwartz | DAL | 1876 |
| Dustin Hopkins | CLE | 1793 |
| Ryan Stonehouse | DET | 1657 |
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