| Justin Herbert | LAC | 4902 | Jalen Hurts | PHI | 4308 | Jared Goff | DET | 4251 | Baker Mayfield | TB | 4179 | C.J. Stroud | HOU | 4177 |
| Bijan Robinson | ATL | 2889 | Jordan Mason | MIN | 1839 | Rico Dowdle | PIT | 1817 | Cam Skattebo | NYG | 1751 | Javonte Williams | DAL | 1699 |
| Malik Nabers | NYG | 1679 | Cooper Kupp | SEA | 1399 | DeVonta Smith | PHI | 1368 | Ja'Marr Chase | CIN | 1323 | Nico Collins | HOU | 1277 |
| Kyle Pitts Sr | ATL | 1056 | Theo Johnson | NYG | 1016 | Dallas Goedert | PHI | 888 | Tyler Warren | IND | 859 | Brock Bowers | LV | 823 |
Defensive Leaders
| Alex Highsmith | PIT | 16.5 | James Pearce Jr | ATL | 15.5 | DeMarcus Lawrence | SEA | 14.0 | Abdul Carter | NYG | 13.5 | Jared Verse | CLE | 13.5 |
| Robert Spillane | NE | 92 | Roquan Smith | BAL | 84 | Cody Barton | TEN | 84 | Daiyan Henley | LAC | 81 | Henry To'oTo'o | HOU | 80 |
| Carlton Davis III | NE | 9 | Christian Gonzalez | NE | 8 | Kenny Moore II | CLE | 8 | Julian Love | SEA | 6 | Jessie Bates III | ATL | 6 |
| DeMarcco Hellams | ATL | 5 | Antoine Winfield Jr | TB | 4 | Henry To'oTo'o | HOU | 4 | Caleb Banks | MIN | 3 | Joey Bosa | NYG | 3 |
Special Teams Leaders
| Nick Folk | ATL | 166 | Jason Myers | SEA | 144 | Andres Borregales | NE | 144 | Will Reichard | MIN | 141 | Tyler Loop | BAL | 137 |
| Logan Cooke | JAX | 4630 | Jeremy Crawshaw | DEN | 4230 | Corey Bojorquez | CLE | 4207 | Bradley Pinion | MIA | 4064 | Ethan Evans | LAR | 3710 |