| Justin Herbert | LAC | 2900 | Baker Mayfield | TB | 2736 | Jalen Hurts | PHI | 2697 | C.J. Stroud | HOU | 2669 | Jordan Love | GB | 2608 |
| Bijan Robinson | ATL | 1644 | Chuba Hubbard | CAR | 1155 | Cam Skattebo | NYG | 1141 | Jordan Mason | MIN | 1088 | Rico Dowdle | PIT | 1056 |
| Malik Nabers | NYG | 1059 | Cooper Kupp | SEA | 928 | Ja'Marr Chase | CIN | 888 | Nico Collins | HOU | 870 | DeVonta Smith | PHI | 855 |
| Theo Johnson | NYG | 600 | Tyler Warren | IND | 597 | Trey McBride | AZ | 580 | Brock Bowers | LV | 574 | Mark Andrews | BAL | 554 |
Defensive Leaders
| Alex Highsmith | PIT | 10.5 | Jared Verse | CLE | 10.5 | Brian Burns | NYG | 10.0 | Osa Odighizuwa | SF | 9.5 | DeMarcus Lawrence | SEA | 8.5 |
| Kerby Joseph | DET | 57 | Roquan Smith | BAL | 56 | Robert Spillane | NE | 54 | Henry To'oTo'o | HOU | 53 | Terrel Bernard | BUF | 52 |
| Carlton Davis III | NE | 6 | Mike Jackson | CAR | 6 | Kenny Moore II | CLE | 6 | Julian Love | SEA | 4 | Jalen Ramsey | PIT | 4 |
| Antoine Winfield Jr | TB | 3 | Azeez Al-Shaair | HOU | 3 | Caleb Banks | MIN | 3 | Milton Williams | NE | 3 | Joey Bosa | NYG | 3 |
Special Teams Leaders
| Andres Borregales | NE | 100 | Tyler Loop | BAL | 98 | Nick Folk | ATL | 91 | Ka'imi Fairbairn | HOU | 88 | Evan McPherson | CIN | 85 |
| Corey Bojorquez | CLE | 3098 | Logan Cooke | JAX | 3090 | Jeremy Crawshaw | DEN | 2772 | Ethan Evans | LAR | 2515 | Johnny Hekker | KC | 2416 |