| Joe Burrow | CIN | 5258 | Desmond Newman | LV | 5020 | Patrick Mahomes | KC | 4943 | Marc Cohen | MIA | 4731 | Jordan Love | GB | 4310 |
| De'Von Achane | MIA | 3053 | Javonte Williams | DAL | 2062 | James Cook III | BUF | 2027 | Christian McCaffrey | SF | 1668 | Jaylen Warren | PIT | 1556 |
| Xavier Worthy | KC | 1484 | Brock Bowers | LV | 1466 | Ja'Marr Chase | CIN | 1377 | Tee Higgins | CIN | 1356 | J.J. Wayne | WAS | 1213 |
| Brock Bowers | LV | 1466 | Noah Gray | KC | 878 | Dalton Kincaid | BUF | 830 | George Kittle | SF | 825 | Pat Freiermuth | PIT | 810 |
Defensive Leaders
| Will Anderson Jr | HOU | 16.0 | Jonathan Greenard | MIN | 15.5 | Bradley Chubb | LAC | 14.5 | Josh Hines-Allen | JAX | 14.5 | Travon Walker | JAX | 14.0 |
| Jihaad Campbell | PHI | 90 | Drew Sanders | JAX | 85 | Jack Gibbens | WAS | 85 | T.J. Edwards | CHI | 81 | Nakobe Dean | MIN | 81 |
| Fred Warner | SF | 6 | Brian Branch | LV | 5 | Jaycee Horn | CAR | 5 | Christian Benford | BUF | 5 | Max Melton | ARI | 4 |
| Jordan Whitehead | LV | 5 | Kenneth Grant | MIA | 5 | Carson Bruener | PIT | 5 | DeShon Elliott | PIT | 5 | Patrick Queen | PIT | 5 |
Special Teams Leaders
| Brandon Aubrey | DAL | 148 | Tyler Bass | BUF | 141 | Daniel Carlson | LV | 140 | Harrison Butker | KC | 139 | Cameron Dicker | NE | 127 |
| Corey Bojorquez | CAR | 3898 | Matthew Hayball | ATL | 3524 | Ryan Stonehouse | CIN | 3105 | Michael Dickson | SEA | 3074 | Tory Taylor | CHI | 3063 |