| Joe Burrow | CIN | 4840 | Patrick Mahomes | KC | 4382 | Justin Herbert | LAC | 4177 | Bo Nix | DEN | 4053 | Tyler Shough | NO | 3898 |
| Bijan Robinson | ATL | 1319 | Cam Skattebo | NYG | 1295 | RJ Harvey | DEN | 1266 | Omarion Hampton | LAC | 1255 | Kenneth Walker | KC | 1234 |
| Ja'Marr Chase | CIN | 1679 | Stefon Diggs | IND | 1498 | Amon-Ra St. Brown | DET | 1429 | Tee Higgins | CIN | 1401 | Jordyn Tyson | NO | 1401 |
| Travis Kelce | KC | 898 | Hunter Henry | NE | 788 | Tucker Kraft | GB | 786 | Kenyon Sadiq | NYJ | 746 | Dalton Kincaid | BUF | 743 |
Defensive Leaders
| Micah Parsons | GB | 18.5 | Maxx Crosby | LV | 17.5 | DeMarcus Lawrence | SEA | 16.0 | Zack Baun | PHI | 15.5 | T.J. Watt | PIT | 15.5 |
| Robert Spillane | NE | 109 | Patrick Queen | PIT | 108 | Blake Cashman | MIN | 108 | Divine Deablo | ATL | 107 | Cedric Gray | TEN | 103 |
| Xavier McKinney | GB | 7 | Charvarius Ward Sr | IND | 6 | Quinyon Mitchell | PHI | 6 | Jessie Bates III | ATL | 6 | Kevin Byard III | NE | 6 |
| T.J. Watt | PIT | 5 | Boye Mafe | CIN | 4 | Drue Tranquill | KC | 4 | Rashan Gary | DAL | 4 | Robert Spillane | NE | 3 |
Special Teams Leaders
| Andres Borregales | NE | 140 | Chris Boswell | PIT | 135 | Eddy Pineiro | SF | 134 | Wil Lutz | DEN | 129 | Evan McPherson | CIN | 129 |
| Tommy Townsend | TEN | 4785 | Logan Cooke | JAX | 4546 | Jake Bailey | ATL | 4414 | Jeremy Crawshaw | DEN | 4294 | Thomas Morstead | PIT | 4271 |