| Cam Jackson | ARI | 3653 | Andy Skaggs | IND | 479 | Lionel Staley | NE | 100 | Joel Weatherspoon | SF | 70 |
| Jeff Weatherspoon | BUF | 576 | Jason Johnson | TEN | 543 | Josh Roberts | GB | 540 | Jordan Staley | CHI | 422 | Shelton Thomas | MIN | 306 |
| Jordan Soto | HOU | 746 | Kamryn Pearson | DEN | 721 | Calvin Booth | NO | 667 | Dillon Rivers | CLE | 661 | Devin McInnis | SEA | 470 |
| Kamryn Pearson | DEN | 721 | Devin McInnis | SEA | 470 | Taylor Portillo | LAC | 407 | John Jackson | MIA | 138 | Salvador Moreno | LV | 119 |
Defensive Leaders
| Matthias Teague | SEA | 10.0 | Adrian O'Donnell | IND | 8.0 | Nick Rose | CAR | 4.5 | Connor Baker | NYG | 4.0 | Eric Contreras | CHI | 3.0 |
| Connor Baker | NYG | 68 | Eugene Edmonds | CIN | 59 | Byron Alford | NYJ | 57 | Emanuel Hankins | DAL | 55 | Braxton Hawkins | ARI | 54 |
| Cam Burney | LAC | 3 | Byron Alford | NYJ | 3 | Angelo Baskett | TEN | 2 | Cam McMillian | IND | 2 | Phillip Douglas | WAS | 2 |
| Emanuel Hankins | DAL | 3 | Carl Woodard | SF | 2 | Kamryn Morse | NE | 2 | Connor Baker | NYG | 2 | Adrian O'Donnell | IND | 1 |
Special Teams Leaders
| Jose Drummond | NO | 112 | Warren Bernard | CLE | 80 | Mike Thompson | DET | 57 | Matthew Knoll | NYG | 18 | Austin Henley | NYG | 10 |
| Malcolm Richardson | NYJ | 2826 | Justin Schillinger | CLE | 2809 | Jamie Altman | BUF | 1816 | Conor Palmer | DET | 36 |