| Joe Burrow | CIN | 4912 | Caleb Williams | CHI | 4763 | J.J. McCarthy | MIN | 4722 | Josh Allen | BUF | 4517 | Joshua Booth | NYJ | 4342 |
| Breece Hall | NYJ | 1412 | Josh Jacobs | GB | 1367 | Glenn Wimbley | HOU | 1310 | Christian McCaffrey | SF | 1201 | Jaylen Warren | PIT | 1197 |
| Chris Godwin | TB | 1378 | Brock Bowers | LV | 1351 | DeVonta Smith | PHI | 1267 | Josh Downs | IND | 1238 | Courtland Sutton | DEN | 1234 |
| Brock Bowers | LV | 1351 | Devin Payne | NYJ | 1153 | Luke Schoonmaker | DAL | 1056 | Hunter Henry | NE | 991 | Dalton Kincaid | BUF | 941 |
Defensive Leaders
| Maxx Crosby | LV | 15.5 | Shaquille Johnson | TB | 11.5 | Chase Young | NO | 10.5 | Laiatu Latu | IND | 10.5 | Alim McNeill | DET | 10.0 |
| Dillon Northcutt | CLE | 97 | Roquan Smith | BAL | 92 | Kyzir White | TB | 91 | Jeremiah Owusu-Koramoah | CLE | 89 | Jamin Davis | WAS | 85 |
| Trevon Diggs | DAL | 9 | Martin Emerson Jr | LV | 8 | Minkah Fitzpatrick | PIT | 7 | Patrick Surtain II | DEN | 7 | Jaire Alexander | GB | 6 |
| Patrick Queen | PIT | 4 | Beanie Bishop Jr | PIT | 4 | Jordyn Brooks | MIA | 3 | Micah Parsons | DAL | 3 | Jamal Adams | TEN | 2 |
Special Teams Leaders
| Ka'imi Fairbairn | HOU | 133 | Brendan Baugh | NO | 126 | Daniel Carlson | LV | 123 | Jason Sanders | JAX | 119 | Joshua Karty | CHI | 114 |
| Mitch Wishnowsky | SF | 3469 | Chad Schwartz | DAL | 3298 | Logan Cooke | WAS | 3156 | Ryan Wright | NYG | 2945 | Ryan Stonehouse | DET | 2670 |