Preseason – 34
| WEEK | OPPONENT | RESULTS |
PASSING LEADER |
RUSHING LEADER |
RECEIVING LEADER |
| 1 | L 34 - 48 | M.Nowak 234 | J.James 58 | T.Washington 74 | |
| 2 | W 30 - 14 | B.Purdy 156 | I.Guerendo 56 | J.Smith 73 | |
| 3 | W 13 - 20 | C.Ward 143 | C.McCaffrey 68 | J.Meyers 83 |
Season – 34
| WEEK | OPPONENT | RESULTS |
PASSING LEADER |
RUSHING LEADER |
RECEIVING LEADER |
| 1 | W 9 - 31 | B.Purdy 238 | C.McCaffrey 60 | C.McCaffrey 132 | |
| 2 | W 20 - 23 | B.Purdy 252 | J.Conner 61 | C.McCaffrey 68 | |
| 3 | L 31 - 35 | B.Purdy 352 | C.McCaffrey 66 | C.McCaffrey 144 | |
| 4 | W 35 - 30 | S.Darnold 339 | C.McCaffrey 140 | C.Kupp 81 | |
| 5 | W 27 - 30 | J.Hurts 244 | C.McCaffrey 85 | D.Smith 80 | |
| 7 | W 34 - 37 | B.Purdy 286 | K.Walker III 115 | E.Arroyo 113 | |
| 8 | W 28 - 24 | B.Purdy 198 | C.McCaffrey 168 | C.Sutton 84 | |
| 9 | W 29 - 23 | J.Daniels 225 | C.McCaffrey 147 | D.Samuel Sr 88 | |
| 10 | W 48 - 32 | C.Callahan 311 | C.McCaffrey 128 | B.Aiyuk 130 | |
| 11 | L 31 - 10 | B.Purdy 207 | C.McCaffrey 101 | C.McCaffrey 68 | |
| 12 | W 23 - 33 | B.Purdy 288 | C.McCaffrey 79 | Q.Johnston 136 | |
| 13 | W 6 - 7 | B.Purdy 151 | C.McCaffrey 125 | L.Farrell 47 | |
| 14 | TBD 0 - 0 | - | - | - | |
| 15 | TBD 0 - 0 | - | - | - | |
| 16 | TBD 0 - 0 | - | - | - | |
| 17 | TBD 0 - 0 | - | - | - | |
| 18 | TBD 0 - 0 | - | - | - |
