| Desmond Ridder | ATL | 4385 | Kenny Pickett | PIT | 3935 | Brock Purdy | SF | 2954 | Bailey Zappe | NE | 8 |
| Breece Hall | NYJ | 1292 | Kenneth Walker III | SEA | 1186 | Isiah Pacheco | KC | 891 | Dameon Pierce | HOU | 829 | Rachaad White | TB | 421 |
| George Pickens | PIT | 1311 | Romeo Doubs | GB | 1124 | Christian Watson | GB | 1044 | Chris Olave | NO | 926 | Jameson Williams | DET | 889 |
| Cade Otton | TB | 823 | Jelani Woods | IND | 623 | Daniel Bellinger | NYG | 568 | Jake Tonges | CHI | 112 | Grant Calcaterra | PHI | 101 |
Defensive Leaders
| Kayvon Thibodeaux | NYG | 14.5 | Aidan Hutchinson | DET | 12.0 | Arnold Ebiketie | ATL | 7.0 | George Karlaftis | KC | 4.0 | Devin Lloyd | JAX | 4.0 |
| Jack Jones | NE | 71 | Devin Lloyd | JAX | 69 | Micah McFadden | NYG | 67 | Quay Walker | GB | 67 | Malcolm Rodriguez | DET | 63 |
| Malcolm Rodriguez | DET | 5 | Nick Cross | IND | 4 | Trent McDuffie | KC | 4 | Devin Lloyd | JAX | 3 | Jaquan Brisker | CHI | 3 |
| Devin Lloyd | JAX | 2 | Daniel Hardy | LAR | 2 | Leo Chenal | KC | 1 | Aidan Hutchinson | DET | 1 | Darien Butler | LV | 1 |
Special Teams Leaders
| Matt Araiza | CHI | 2133 | Ryan Wright | MIN | 2062 | Jordan Stout | BAL | 1863 | Jake Camarda | TB | 1703 |