| Desmond Ridder | ATL | 1800 | Kenny Pickett | PIT | 1644 | Brock Purdy | SF | 1288 |
| Breece Hall | NYJ | 576 | Kenneth Walker III | SEA | 420 | Rachaad White | TB | 343 | Isiah Pacheco | KC | 280 | Dameon Pierce | HOU | 227 |
| George Pickens | PIT | 583 | Christian Watson | GB | 464 | Chris Olave | NO | 354 | Jahan Dotson | WAS | 354 | Drake London | ATL | 311 |
| Cade Otton | TB | 284 | Daniel Bellinger | NYG | 250 | Jelani Woods | IND | 233 | Greg Dulcich | DEN | 76 | Jake Tonges | CHI | 48 |
Defensive Leaders
| Kayvon Thibodeaux | NYG | 6.5 | Aidan Hutchinson | DET | 4.0 | Travon Walker | JAX | 3.0 | George Karlaftis | KC | 2.0 | Arnold Ebiketie | ATL | 1.5 |
| Quay Walker | GB | 37 | Jack Jones | NE | 32 | Micah McFadden | NYG | 23 | Trent McDuffie | KC | 21 | Sauce Gardner | NYJ | 21 |
| Nick Cross | IND | 3 | Derek Stingley Jr | HOU | 3 | Malcolm Rodriguez | DET | 2 | Sauce Gardner | NYJ | 2 | Kyler Gordon | CHI | 1 |
| Leo Chenal | KC | 1 | Devin Lloyd | JAX | 1 | Micah McFadden | NYG | 1 | Luke Masterson | LV | 1 | Daniel Hardy | LAR | 1 |
Special Teams Leaders
| Matt Araiza | CHI | 1001 | Jordan Stout | BAL | 964 | Ryan Wright | MIN | 907 | Jake Camarda | TB | 504 |