Preseason – 35
| WEEK | OPPONENT | RESULTS |
PASSING LEADER |
RUSHING LEADER |
RECEIVING LEADER |
| 1 | L 48 - 35 | D.Newman 355 | C.McCaffrey 136 | C.McCaffrey 89 | |
| 2 | W 41 - 20 | A.Skaggs 155 | C.McCaffrey 95 | J.Cowing 46 | |
| 3 | L 31 - 34 | P.Mahomes 199 | C.McCaffrey 66 | X.Worthy 77 |
Season – 35
| WEEK | OPPONENT | RESULTS |
PASSING LEADER |
RUSHING LEADER |
RECEIVING LEADER |
| 1 | L 24 - 14 | B.Purdy 262 | J.Warren 77 | B.Aiyuk 91 | |
| 2 | W 45 - 24 | C.Callahan 267 | C.McCaffrey 116 | R.Pearsall 78 | |
| 3 | W 31 - 34 | C.Williams 315 | C.McCaffrey 138 | C.Loveland 96 | |
| 4 | L 26 - 23 | B.Purdy 189 | C.McCaffrey 109 | J.Meyers 68 | |
| 5 | W 39 - 27 | E.Medina 235 | C.McCaffrey 193 | J.Smith-Schuster 79 | |
| 6 | W 19 - 17 | J.McCarthy 183 | C.McCaffrey 184 | B.Aiyuk 68 | |
| 7 | W 14 - 24 | B.Purdy 150 | L.Jackson 100 | G.Kittle 60 | |
| 8 | L 13 - 35 | B.Purdy 295 | J.Williams 131 | R.Pearsall 87 | |
| 9 | W 3 - 44 | B.Purdy 252 | C.McCaffrey 110 | A.Cooper 77 | |
| 10 | W 27 - 24 | B.Purdy 336 | C.McCaffrey 163 | T.McBride 136 | |
| 11 | L 37 - 34 | B.Purdy 248 | C.McCaffrey 144 | E.Egbuka 94 | |
| 12 | W 31 - 10 | B.Purdy 237 | C.McCaffrey 95 | C.Mulligan 76 | |
| 14 | L 31 - 38 | J.Burrow 445 | C.McCaffrey 44 | T.Higgins 189 | |
| 15 | W 17 - 28 | B.Purdy 198 | C.Jackson 47 | G.Kittle 99 | |
| 16 | TBD 0 - 0 | - | - | - | |
| 17 | TBD 0 - 0 | - | - | - | |
| 18 | TBD 0 - 0 | - | - | - |
