| Tua Tagovailoa | MIA | 5505 | Joe Burrow | CIN | 5289 | Josh Allen | BUF | 5239 | Caleb Williams | CHI | 4840 | Michael Penix Jr | ATL | 4733 |
| Jaylen Warren | PIT | 2261 | Javonte Williams | DAL | 2014 | De'Von Achane | MIA | 1877 | Ashton Jeanty | LV | 1835 | James Cook III | BUF | 1713 |
| Tyreek Hill | MIA | 1796 | Rome Odunze | CHI | 1755 | Puka Nacua | LAR | 1444 | Ja'Marr Chase | CIN | 1386 | Dalton Kincaid | BUF | 1339 |
| Dalton Kincaid | BUF | 1339 | Kyle Pitts | ATL | 1229 | George Kittle | SF | 1221 | Colston Loveland | CHI | 1183 | Brock Bowers | LV | 1041 |
Defensive Leaders
| Jared Verse | LAR | 16.0 | Tuli Tuipulotu | LAC | 14.5 | Aidan Hutchinson | DET | 14.5 | Jonathan Greenard | MIN | 14.0 | Abdul Carter | NYG | 14.0 |
| Quincy Williams | NYJ | 108 | Logan Wilson | CIN | 107 | Foyesade Oluokun | JAX | 98 | Daiyan Henley | LAC | 97 | Blake Cashman | MIN | 91 |
| Minkah Fitzpatrick | MIA | 8 | Nick Cross | IND | 7 | Jevon Holland | NYG | 6 | Marlon Humphrey | BAL | 6 | Derek Stingley Jr | HOU | 6 |
| Quincy Williams | NYJ | 7 | Jamien Sherwood | NYJ | 5 | Roquan Smith | BAL | 5 | Donovan Wilson | DAL | 4 | Yetur Gross-Matos | SF | 4 |
Special Teams Leaders
| Tyler Bass | BUF | 138 | Riley Patterson | MIA | 133 | Chris Boswell | PIT | 133 | Andres Borregales | NE | 123 | Cairo Santos | CHI | 121 |
| Michael Dickson | SEA | 3117 | Jack Browning | NYJ | 3098 | Ethan Evans | LAR | 3028 | Ryan Wright | MIN | 3015 | Daniel Whelan | GB | 2916 |