| Josh Allen | BUF | 5767 | Patrick Mahomes | KC | 5093 | Trevor Lawrence | JAX | 4797 | Joe Burrow | CIN | 4575 | George Johnson | LAR | 4351 |
| Tony Pollard | DAL | 2656 | Deionte Rich | HOU | 1868 | Cam Akers | LAR | 1623 | Christian McCaffrey | SF | 1606 | Jonathan Taylor | IND | 1586 |
| Stefon Diggs | BUF | 2186 | CeeDee Lamb | DAL | 1992 | Davante Adams | LV | 1953 | Christian Kirk | JAX | 1450 | Cooper Kupp | LAR | 1449 |
| Travis Kelce | KC | 1372 | Dawson Knox | BUF | 1208 | George Kittle | SF | 1037 | Gerald Everett | LAC | 1003 | Michael Mayer | LV | 952 |
Defensive Leaders
| Nick Bosa | SF | 25.5 | Aaron Donald | LAR | 14.0 | Jonathan Allen | WAS | 12.0 | Azeez Ojulari | NYG | 12.0 | Harold Landry III | TEN | 12.0 |
| Shaq Thompson | CAR | 110 | Eric Kendricks | LAC | 94 | Azeez Al-Shaair | TEN | 93 | De'Vondre Campbell | GB | 93 | Nicholas Morrow | PHI | 93 |
| Trevon Diggs | DAL | 12 | Kenny Moore II | IND | 7 | Tre'Davious White | BUF | 7 | Ryan Neal | TB | 6 | Taron Johnson | BUF | 6 |
| Damone Clark | DAL | 3 | Divine Deablo | LV | 2 | Joey Bosa | LAC | 2 | Dre Greenlaw | SF | 2 | Quincey Basnight | KC | 2 |
Special Teams Leaders
| Bradley O'Connell | WAS | 118 | Jason Myers | SEA | 110 | Tyler Bass | BUF | 110 | Brandon Aubrey | DAL | 110 | Brett Maher | LAR | 104 |
| Jake Camarda | TB | 3043 | Ryan Stonehouse | ARI | 3005 | Corey Bojorquez | TEN | 2773 | J.K. Scott | LAC | 2756 | Michael Dickson | SEA | 2727 |