| Jeff Weatherspoon | BUF | 177 | Brandon Reede | DAL | 169 | Jordan Staley | CHI | 100 | Maurice Hoover | CIN | 63 | Josh Roberts | GB | 52 |
| Calvin Booth | NO | 115 | Kamryn Pearson | DEN | 112 | Devin McInnis | SEA | 39 | Joshua Hightower | DAL | 28 | Dillon Rivers | CLE | 27 |
| Kamryn Pearson | DEN | 112 | Devin McInnis | SEA | 39 | John Morales | TEN | 18 | Salvador Moreno | LV | 15 | John Jackson | MIA | 5 |
Defensive Leaders
| Connor Baker | NYG | 2.0 | Adrian O'Donnell | IND | 2.0 | Joshua Westbrook | HOU | 1.0 | Tony Gleason | CIN | 1.0 | Corey McIntyre | NYG | 0.5 |
| Emanuel Hankins | DAL | 10 | Carlos Barnett | DET | 10 | Eugene Edmonds | CIN | 10 | Carl Woodard | SF | 9 | Cam Burney | LAC | 7 |
| LaDarius Pierce | SF | 1 | Emanuel Hankins | DAL | 1 | Carl Woodard | SF | 0 | Tyrell McClain | SF | 0 | Ryan Hartman | MIN | 0 |
| Connor Baker | NYG | 1 | Carl Woodard | SF | 0 | Tyrell McClain | SF | 0 | LaDarius Pierce | SF | 0 | Ryan Hartman | MIN | 0 |
Special Teams Leaders
| Matthew Knoll | NYG | 18 | Warren Bernard | CLE | 14 | Jose Drummond | NO | 12 | Mike Thompson | DET | 8 | Austin Henley | NYG | 1 |
| Justin Schillinger | CLE | 323 | Malcolm Richardson | NYJ | 220 | Jamie Altman | BUF | 122 |