| Josh Roberts | GB | 443 | Jeff Weatherspoon | BUF | 406 | Jason Johnson | TEN | 403 | Jordan Staley | CHI | 393 | Brandon Reede | DAL | 251 |
| Kamryn Pearson | DEN | 584 | Jordan Soto | HOU | 551 | Calvin Booth | NO | 528 | Dillon Rivers | CLE | 526 | Devin McInnis | SEA | 390 |
| Kamryn Pearson | DEN | 584 | Devin McInnis | SEA | 390 | Taylor Portillo | LAC | 320 | Salvador Moreno | LV | 119 | John Jackson | MIA | 113 |
Defensive Leaders
| Matthias Teague | SEA | 8.0 | Adrian O'Donnell | IND | 8.0 | Nick Rose | CAR | 4.0 | Connor Baker | NYG | 4.0 | Eric Contreras | CHI | 3.0 |
| Connor Baker | NYG | 59 | Emanuel Hankins | DAL | 46 | Braxton Hawkins | ARI | 45 | Byron Alford | NYJ | 45 | Angelo Baskett | TEN | 45 |
| Byron Alford | NYJ | 3 | Angelo Baskett | TEN | 2 | Phillip Douglas | WAS | 2 | Bryan Buchanan | PIT | 2 | Jordan Curtis | CHI | 1 |
| Emanuel Hankins | DAL | 3 | Carl Woodard | SF | 2 | Connor Baker | NYG | 2 | Adrian O'Donnell | IND | 1 | Kamryn Morse | NE | 1 |
Special Teams Leaders
| Jose Drummond | NO | 90 | Warren Bernard | CLE | 57 | Mike Thompson | DET | 57 | Matthew Knoll | NYG | 18 | Austin Henley | NYG | 4 |
| Malcolm Richardson | NYJ | 2502 | Justin Schillinger | CLE | 2252 | Jamie Altman | BUF | 1560 | Conor Palmer | DET | 36 |