| Jordan Staley | CHI | 393 | Josh Roberts | GB | 283 | Jason Johnson | TEN | 276 | Jeff Weatherspoon | BUF | 229 | Brandon Reede | DAL | 203 |
| Calvin Booth | NO | 348 | Dillon Rivers | CLE | 346 | Kamryn Pearson | DEN | 318 | Jamaal Northrop | NE | 249 | Devin McInnis | SEA | 217 |
| Kamryn Pearson | DEN | 318 | Devin McInnis | SEA | 217 | Salvador Moreno | LV | 111 | Braxton Stephenson | PIT | 95 | Taylor Portillo | LAC | 58 |
Defensive Leaders
| Adrian O'Donnell | IND | 5.5 | Connor Baker | NYG | 3.0 | Bryan Buchanan | PIT | 2.5 | Nick Rose | CAR | 2.0 | Eric Contreras | CHI | 2.0 |
| Eugene Edmonds | CIN | 31 | Connor Baker | NYG | 31 | Ryan Hartman | MIN | 28 | Maurice Best | PHI | 27 | Angelo Baskett | TEN | 26 |
| Phillip Douglas | WAS | 1 | Cam McMillian | IND | 1 | Moses Phelps | KC | 1 | Byron Alford | NYJ | 1 | Emanuel Hankins | DAL | 1 |
| Connor Baker | NYG | 2 | Carl Woodard | SF | 1 | Josh Clements | NE | 1 | Bryan Buchanan | PIT | 1 | Emanuel Hankins | DAL | 1 |
Special Teams Leaders
| Jose Drummond | NO | 50 | Warren Bernard | CLE | 44 | Matthew Knoll | NYG | 18 | Austin Henley | NYG | 1 | Justin Schillinger | CLE | 0 |
| Malcolm Richardson | NYJ | 1471 | Justin Schillinger | CLE | 1084 | Jamie Altman | BUF | 728 | Conor Palmer | DET | 36 |