| Tua Tagovailoa | MIA | 1325 | Joe Burrow | CIN | 1296 | Christopher Callahan | LAR | 1288 | Caleb Williams | CHI | 1280 | Eric Medina | CLE | 971 |
| Jaylen Warren | PIT | 619 | Bijan Robinson | ATL | 548 | De'Von Achane | MIA | 462 | Javonte Williams | DAL | 420 | Ashton Jeanty | LV | 400 |
| Ja'Marr Chase | CIN | 642 | Puka Nacua | LAR | 433 | Rome Odunze | CHI | 387 | Luther Burden III | CHI | 387 | Tyreek Hill | MIA | 330 |
| David Njoku | CLE | 279 | Colston Loveland | CHI | 239 | Kyle Pitts | ATL | 215 | Elijah Arroyo | SEA | 183 | Dalton Schultz | HOU | 180 |
Defensive Leaders
| Myles Garrett | CLE | 9.5 | Micah Parsons | GB | 5.5 | Shemar Stewart | CIN | 4.5 | Jeffery Simmons | TEN | 4.5 | Brandon Dorlus | ATL | 4.0 |
| Shaq Thompson | CAR | 24 | Jeremiah Owusu-Koramoah | CLE | 20 | Tremaine Edmunds | CHI | 19 | Carson Schwesinger | CLE | 19 | Edgerrin Cooper | GB | 19 |
| Sean Murphy-Bunting | ARI | 2 | Brian Branch | DET | 2 | Kader Kohou | MIA | 2 | Derwin James Jr | LAC | 2 | Jonathan Jones | DAL | 2 |
| Troy Andersen | ATL | 3 | Patrick Queen | PIT | 2 | Taylor Rapp | BUF | 2 | Terrel Bernard | BUF | 2 | Myles Garrett | CLE | 2 |
Special Teams Leaders
| Brandon Aubrey | DAL | 37 | Chris Boswell | PIT | 32 | Eddy Pineiro | CLE | 30 | Matt Gay | LAR | 28 | Jake Bates | MIA | 27 |
| Corey Bojorquez | CLE | 1085 | Michael Palardy | GB | 808 | J.K. Scott | LAC | 698 | Tommy Townsend | HOU | 692 | Jake Bailey | CAR | 675 |