| Christopher Callahan | LAR | 5314 | Joe Burrow | CIN | 5034 | Tua Tagovailoa | MIA | 4719 | Patrick Mahomes | KC | 4516 | Justin Herbert | LAC | 4083 |
| Javonte Williams | DAL | 2521 | James Cook III | BUF | 2360 | Ashton Jeanty | LV | 2096 | Jaylen Warren | PIT | 2086 | De'Von Achane | MIA | 1775 |
| Ja'Marr Chase | CIN | 1583 | Puka Nacua | LAR | 1545 | Rashee Rice | KC | 1379 | Tyreek Hill | MIA | 1279 | Rome Odunze | CHI | 1205 |
| Noah Gray | KC | 819 | Elijah Arroyo | SEA | 754 | Mark Andrews | BAL | 747 | Brock Bowers | LV | 744 | Hunter Henry | NE | 735 |
Defensive Leaders
| Myles Garrett | CLE | 24.0 | Nic Scourton | CAR | 15.5 | Bradley Chubb | LAC | 15.0 | Aidan Hutchinson | DET | 14.5 | Steven Long | TB | 14.5 |
| Edgerrin Cooper | GB | 101 | Robert Spillane | NE | 93 | Kenneth Murray Jr | TB | 87 | Krys Barnes | NO | 86 | Jimmy Smiley | IND | 82 |
| Roquan Smith | BAL | 6 | Jerry Banks | DAL | 6 | Malik Hooker | DAL | 6 | Bobby Wagner | NYJ | 5 | Cole Bishop | BUF | 5 |
| Jack Campbell | DET | 6 | Patrick Queen | PIT | 5 | Elandon Roberts | LAC | 4 | Taylor Rapp | BUF | 4 | Myles Garrett | CLE | 4 |
Special Teams Leaders
| Brandon Aubrey | DAL | 168 | Tyler Bass | BUF | 138 | Tyler Loop | BAL | 128 | Chris Boswell | PIT | 123 | Jake Moody | SF | 122 |
| Corey Bojorquez | CLE | 3960 | Ryan Wright | MIN | 3165 | Tommy Townsend | HOU | 3097 | Jake Bailey | CAR | 3058 | Michael Palardy | GB | 2988 |