| Joe Burrow | CIN | 5797 |
| Patrick Mahomes | KC | 5359 |
| Joe Milton III | CLE | 5146 |
| Jared Goff | DET | 5030 |
| C.J. Stroud | HOU | 4999 |
| Nick Chubb | CLE | 2051 |
| Ty Chandler | HOU | 1671 |
| Aaron Jones | MIN | 1424 |
| Kenneth Walker III | SEA | 1369 |
| Ezekiel Elliott | DAL | 1344 |
| Justin Jefferson | MIN | 1754 |
| Amon-Ra St. Brown | DET | 1668 |
| Tee Higgins | CIN | 1668 |
| Josh Downs | IND | 1539 |
| Rashee Rice | KC | 1513 |
| David Njoku | CLE | 1458 |
| Travis Kelce | KC | 1199 |
| Mark Andrews | BAL | 1124 |
| Kyle Pitts | ATL | 1118 |
| Tyler Conklin | NYJ | 946 |
Defensive Leaders
| Myles Garrett | CLE | 23.0 |
| Khalil Mack | LAC | 12.0 |
| Andrew Van Ginkel | MIN | 11.0 |
| Matthew Judon | ATL | 9.5 |
| Montez Sweat | CHI | 9.5 |
| Jerome Baker | SEA | 86 |
| Quay Walker | GB | 84 |
| Demario Davis | NO | 82 |
| Willie Gay | NO | 82 |
| Harrison Smith | MIN | 80 |
| Denzel Ward | CLE | 9 |
| Micah Hyde | KC | 8 |
| Patrick Queen | PIT | 7 |
| Xavier McKinney | GB | 7 |
| Jessie Bates III | ATL | 7 |
| Harrison Smith | MIN | 5 |
| Kyle Hamilton | BAL | 4 |
| Quinnen Williams | NYJ | 4 |
| Jamal Adams | TEN | 4 |
| Sauce Gardner | NYJ | 3 |
Special Teams Leaders
| Dustin Hopkins | CLE | 151 |
| Ka'imi Fairbairn | HOU | 146 |
| Will Reichard | MIN | 134 |
| Joshua Karty | LAR | 129 |
| Justin Tucker | BAL | 126 |
| Blake Gillikin | ARI | 2842 |
| Jake Bailey | MIA | 2679 |
| Ryan Stonehouse | TEN | 2625 |
| Jake Camarda | TB | 2504 |
| Riley Dixon | DEN | 2329 |
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