| Marc Cohen | MIA | 1587 | Joe Burrow | CIN | 1479 | Desmond Newman | LV | 1430 | Patrick Mahomes | KC | 1223 | Jayden Daniels | WAS | 1166 |
| De'Von Achane | MIA | 766 | Javonte Williams | DAL | 737 | James Cook III | BUF | 579 | Jaylen Warren | PIT | 450 | Christian McCaffrey | SF | 436 |
| Brock Bowers | LV | 521 | Joey Holloway | ATL | 439 | Jameson Williams | MIA | 425 | George Pickens | DAL | 414 | Tee Higgins | CIN | 414 |
| Brock Bowers | LV | 521 | Erick All Jr | CIN | 262 | Dalton Schultz | HOU | 234 | David Njoku | CLE | 216 | Dalton Kincaid | BUF | 212 |
Defensive Leaders
| Ed Oliver | BUF | 6.0 | Chase Young | NO | 5.5 | Will Anderson Jr | HOU | 5.0 | Jordan Burch | ARI | 5.0 | Danielle Hunter | HOU | 5.0 |
| Troy Andersen | ATL | 31 | Kevin Winston Jr. | WAS | 31 | JD Bertrand | ATL | 29 | Dre Greenlaw | DEN | 28 | Bryan Cook | MIA | 27 |
| Dru Phillips | NYG | 3 | Jerry DeVoe | CIN | 3 | Carson Schwesinger | LAR | 2 | Brian Branch | LV | 2 | Jaycee Horn | CAR | 2 |
| Patrick Queen | PIT | 3 | Connor Baker | NYG | 2 | Kamren Kinchens | LAR | 2 | Markquese Bell | DAL | 2 | Tremaine Edmunds | ARI | 2 |
Special Teams Leaders
| Brandon Aubrey | DAL | 46 | Tyler Bass | BUF | 44 | Harrison Butker | KC | 42 | Cade York | NE | 40 | Mike Thompson | DET | 37 |
| Matthew Hayball | ATL | 979 | Corey Bojorquez | CAR | 947 | Bradley Pinion | TEN | 852 | Braden Mann | NYG | 800 | Michael Dickson | SEA | 779 |