| Joe Burrow | CIN | 3270 | Christopher Callahan | LAR | 3163 | Tua Tagovailoa | MIA | 2851 | Caleb Williams | CHI | 2668 | Patrick Mahomes | KC | 2657 |
| James Cook III | BUF | 1708 | Ashton Jeanty | LV | 1421 | Javonte Williams | DAL | 1336 | De'Von Achane | MIA | 1269 | Jaylen Warren | PIT | 1167 |
| Ja'Marr Chase | CIN | 1245 | Puka Nacua | LAR | 933 | Rome Odunze | CHI | 840 | Rashee Rice | KC | 794 | DeVonta Smith | PHI | 786 |
| Dalton Kincaid | BUF | 533 | Brock Bowers | LV | 532 | Mark Andrews | BAL | 496 | Colston Loveland | CHI | 479 | Noah Gray | KC | 474 |
Defensive Leaders
| Myles Garrett | CLE | 15.0 | Shemar Stewart | CIN | 10.5 | Mike Green | BAL | 10.0 | Jeffery Simmons | TEN | 9.0 | Nik Bonitto | DEN | 8.5 |
| Shaq Thompson | CAR | 63 | Micah McFadden | NYG | 56 | Krys Barnes | NO | 56 | Edgerrin Cooper | GB | 53 | Derek Stingley Jr | HOU | 52 |
| Malik Hooker | DAL | 6 | Cole Bishop | BUF | 5 | Rasul Douglas | PIT | 5 | Khaleke Hudson | MIN | 4 | Bobby Wagner | NYJ | 4 |
| Taylor Rapp | BUF | 4 | Logan Wilson | CIN | 3 | Patrick Queen | PIT | 3 | Jack Campbell | DET | 3 | Terrel Bernard | BUF | 3 |
Special Teams Leaders
| Brandon Aubrey | DAL | 109 | Tyler Bass | BUF | 96 | Tyler Loop | BAL | 82 | Chris Boswell | PIT | 82 | Jake Moody | SF | 82 |
| Corey Bojorquez | CLE | 2339 | Tommy Townsend | HOU | 2058 | Jake Bailey | CAR | 2000 | Ryan Stonehouse | CIN | 1950 | Michael Palardy | GB | 1893 |